孙少平,男,1980年出生,博士,教授,硕士生导师。
现任制药工程系主任。2010年毕业于沈阳药科大学,并获得药剂学博士学位。2009-2010年于日本爱知学院大学访学。2011至2015年在澳门大学、黑龙江大学开展药物新剂型方面的博士后研究工作。
受聘为中国颗粒学会青年理事、中国颗粒学会药物制剂与粒子设计委员会委员、中国生物材料学会会员、吉林大学艾滋病疫苗国家工程实验室特聘专家等。担任“Carbohydrate Polymers”、“International Journal of Nanomedicine”、“Cells”等国际SCI刊物特约审稿人。
主要从事药剂学领域的研究工作,包括新型药用载体材料、药物新剂型以及抗肿瘤药物、抗糖尿病药物等生物大分子药物微粒给药系统的研究工作。主持承担国家自然科学基金、黑龙江省自然科学基金、中国博士后基金、黑龙江省博士后基金、黑龙江省省属高校科技成果研发项目、哈尔滨市科技创新项目等多项课题;获得授权中国发明专利5项,已实现成果转化2项,为企业创造了较高的经济效益。作为第一或通讯作者,至今已在“Carbohydrate Polymers”等国际著名期刊上发表SCI论文30余篇。作为主编出版专著一部,作为指导教师带领学生获得国家制药工程大赛二等奖、黑龙江省创新创业大赛一等奖等成绩。
联系方式:18245027806;sunshaoping111@163.com
一、 研究方向
从事药剂学领域的研究工作,新型药用载体材料、药物新剂型以及抗肿瘤药物、抗糖尿病药物等生物大分子药物微粒给药系统的研究工作。
讲授课程: 工业药剂学,工业药剂学实验等
二、 主持科研项目情况
主持承担国家自然科学基金、黑龙江省自然科学基金、中国博士后基金、黑龙江省博士后基金、黑龙江省省属高校科技成果研发项目、哈尔滨市科技创新项目等多项课题。
三、 发表学术论文情况
代表作:
1. Haohui Shi, Na Liang, Jiyang Liu, Siyi Li, Xianfeng Gong, Pengfei Yan, Shaoping Sun*, AIE-active polymeric micelles based on modified chitosan for bioimaging-guided targeted delivery and controlled release of paclitaxel, Carbohydrate Polymers, 2021, 269: 118327.
2. Siyi Li, Na Liang, Pengfei Yan, Yoshiaki Kawashima, Shaoping Sun*, Inclusion complex based on N-acetyl-L-cysteine and arginine modified hydroxypropyl-β-cyclodextrin for oral insulin delivery, Carbohydrate Polymers, 2021, 252: 117202.
3. Yang Han, Jieyi Pan, Na Liang, Xianfeng Gong, Shaoping Sun*, A pH-sensitive polymeric micellar system based on chitosan derivative for efficient delivery of paclitaxel, International Journal of Molecular Sciences, 2021, 22(13): 6659.
4. Jiyang Liu, Na Liang, Shupeng Li, Yang Han, Pengfei Yan, Yoshiaki Kawashima, Fude Cui, Shaoping Sun*, Tumor-targeting and redox-sensitive micelles based on hyaluronic acid conjugate for delivery of paclitaxel, Journal of Biomaterials Applications, 2020, 34(10): 1458-1469.
5. Shupeng Li, Wei Zhao, Na Liang, Yingxue Xu, Yoshiaki Kawashima, Shaoping Sun*, Multifunctional micelles self-assembled from hyaluronic acid conjugate for enhancing anti-tumor effect of paclitaxel, Reactive and Functional Polymers, 2020, 152: 104608.
6. Yang Han, Na Liang, Pengfei Yan, Yoshiaki Kawashima, Fude Cui, Shaoping Sun*, A chitosan-based micellar system as nanocarrier for the delivery of paclitaxel, Polymers, 2020, 12(2): 380.
7. Xin Zhang, Na Liang, Xianfeng Gong, Yoshiaki Kawashima, Fude Cui, Shaoping Sun*, Tumor-targeting micelles based on folic acid and α-tocopherol succinate conjugated hyaluronic acid for paclitaxel delivery, Colloids and Surfaces B: Biointerfaces, 2019, 177: 11-18.
8. Caixia Yan, Na Liang, Qiang Li, Pengfei Yan, Shaoping Sun*, Biotin and arginine modified hydroxypropyl-β-cyclodextrin nanoparticles as novel drug delivery systems for paclitaxel, Carbohydrate Polymers, 2019, 216: 129-139.
9. Danfeng Wang, Na Liang, Yoshiaki Kawashima, Fude Cui, Pengfei Yan, Shaoping Sun*, Biotin-modified bovine serum albumin nanoparticles as a potential drug delivery system for paclitaxel, Journal of Materials Science, 2019, 54(11): 8613-8626.
10. Na Liang, Shaoping Sun*, Xianfeng Gong, Qiang Li, Pengfei Yan, Fude Cui, Polymeric micelles based on modified glycol chitosan for paclitaxel delivery: Preparation, characterization and evaluation, International Journal of Molecular Sciences, 2018, 19(6): 1550.
11. Liang Li, Na Liang, Danfeng Wang, Pengfei Yan, Yoshiaki Kawashima, Fude Cui, Shaoping Sun*, Amphiphilic polymeric micelles based on deoxycholic acid and folic acid modified chitosan for the delivery of paclitaxel, International Journal of Molecular Sciences, 2018, 19(10): 3132.
12. Shaoping Sun, Na Liang, Xianfeng Gong, Weiwei An, Yoshiaki Kawashima, Fude Cui, Pengfei Yan, Multifunctional composite microcapsules for oral delivery of insulin, International Journal of Molecular Sciences, 2016, 18(1): 54.
13. Na Liang, Shaoping Sun*, Juan Hong, Jingzhuo Tian, Liang Fang, Fude Cui, In vivo pharmacokinetics, biodistribution and antitumor effect of paclitaxel-loaded micelles based on α-tocopherol succinate-modified chitosan, Drug Delivery, 2016, 23(8): 2651-2660.
14. Shaoping Sun, Na Liang, Hiromitsu Yamamoto, Yoshiaki Kawashima, Fude Cui, Pengfei Yan, pH-sensitive poly(lactide-co-glycolide) nanoparticle composite microcapsules for oral delivery of insulin, International Journal of Nanomedicine, 2015, 10: 3489-3498.
15. Na Liang, Shaoping Sun, Xuefeng Li, Hongze Piao, Hongyu Piao, Fude Cui, Liang Fang, α-Tocopherol succinate-modified chitosan as a micellar delivery system for paclitaxel: Preparation, characterization and in vitro/in vivo evaluations, International Journal of Pharmaceutics, 2012, 423(2): 480-488.
16. Shaoping Sun, Na Liang, Yoshiaki Kawashima, Dengning Xia, Fude Cui, Hydrophobic ion pairing of an insulin-sodium deoxycholate complex for oral delivery of insulin, International Journal of Nanomedicine, 2011, 6: 3049-3056.
17. Shaoping Sun, Na Liang, Hongze Piao, Hiromitsu Yamamoto, Yoshiaki Kawashima, Fude Cui, Insulin-S.O (sodium oleate) complex-loaded PLGA nanoparticles: Formulation, characterization and in vivo evaluation, Journal of Microencapsulation, 2010, 27(6): 471-478.
四、 授权专利情况:
申请中国发明专利10余项,已获授权发明专利5项,其中转让2项。
五、 学术著作情况:
孙少平,梁娜,《高分子材料在纳米给药系统中的应用》,黑龙江大学出版社,2017.
六、 人才培养
培养(在读)硕博士研究生20余名,作为指导教师带领学生获得国家制药工程大赛二等奖、黑龙江省创新创业大赛一等奖等成绩。
竞赛获奖:
1. 王雪,杨振乾,雷碧仙,陈冬阳,孙婧怡,李燕珊。第九届全国大学生制药工程设计竞赛,二等奖(指导教师)
2. 张剑锋,杨振乾,陈孝兰,周海平,于晓凡。第八届全国大学生制药工程设计竞赛,三等奖(指导教师)
3. 龙学玲,宫雷,李思怡,徐映雪,赵薇。第六届黑龙江省“互联网+”大学生创新创业大赛,金奖(指导教师)